Curisafe (Cefadroxil monohydrate) Is abactericidal first generation cepnalosporin. It interferes with the terminal step in bacterial cell-wall synthesis and, thereby,
exerts a bactericidal activity against both Gram-positive and Gram-negative
microorganisms. Cefadroxil is markedly resistant to hydrolysis by beta-
lactamase. As a result, all infections caused by bacteria that elaborate this
enzyme are efficiently treated with Curisafe.
Kinetic Properties :
Curisafe is readily absorbed from GIT without being affected by gastric acid or the presence of food. Peak blood concentrations are achieved vvitldll 1.5 to 2 1I00ls dlld llleasurable levels are prtisenr12 hours after oral administration . The drug is eliminated from the body unchanged in the urine with a plasma half-life of about 1.5 hours. The urine-Curisafe concentration is maintained well above the MIC of susceptible urinary pathogens throughout the dosing interval (12 hours).
Bactericidal Spectrum :
Curisafe exhibits an outstanding effectiveness against a wide range
of Gram-positive pathogens including beta-Iactamase and non-beta-
lactamase producing staphylococcl.f-hernotytlc streptococci,
Streptococcus pneumoniae and Streptococcus pyoqene . Itisals()tlffe ve
aqains severar Gram-negative organisms such as Escherichia coli,
Klebsiella pneumoniae and some strains of Proteus mirabilis, Haemophilus
species and Shigella species.
Curisafe is indicated in the treatment of infections caused by susceptible
strains of Gram-positive and Gram-negative bacteria:
* Infections of the Respiratory Tract; such as tonsillitis, pharyngitis,
laryngitis, bronchitis, bronchopneumonia, bronchiectasis, pulmonary
abscess, empyema, pleurisy, sinusitis.Slnd otitis media.
* Infections of the Skin and Soft Tissues; such as cellulitis, erysipelas,
pyodermia, lymphangitis, abscesses, decubitus ulcers, mastitis,
furunculosis, impetigo and infected traumatic and postoperative wounds.
* Infections of the Genitourinary Tract; such as pyelonephritis, cystitis,
urethritis, adnexitis, endometritis and other gynecologic infections.
* Other Infections of the Body; such as osteomyelitis, septic arthritis,
intraabdominal infections and dental infections.