CURISAFE 125MG/5ML-Egypt

Pharco Corporation

Properties :

Curisafe (Cefadroxil monohydrate) Is abactericidal first generation cepnalosporin. It interferes with the terminal step in bacterial cell-wall synthesis and, thereby,

exerts a bactericidal activity against both Gram-positive and Gram-negative
microorganisms. Cefadroxil is markedly resistant to hydrolysis by beta-
lactamase. As a result, all infections caused by bacteria that elaborate this
enzyme are efficiently treated with Curisafe.

Kinetic Properties :

Curisafe is readily absorbed from GIT without being affected by gastric acid or the presence of food. Peak blood concentrations are achieved vvitldll 1.5 to 2 1I00ls dlld llleasurable levels are prtisenr12 hours after oral administration . The drug is eliminated from the body unchanged in the urine with a plasma half-life of about 1.5 hours. The urine-Curisafe concentration is maintained well above the MIC of susceptible urinary pathogens throughout the dosing interval (12 hours).

Bactericidal Spectrum :

Curisafe exhibits an outstanding effectiveness against a wide range of Gram-positive pathogens including beta-Iactamase and non-beta- lactamase producing staphylococcl.f-hernotytlc streptococci, Streptococcus pneumoniae and Streptococcus pyoqene . Itisals()tlffe ve aqains severar Gram-negative organisms such as Escherichia coli, Klebsiella pneumoniae and some strains of Proteus mirabilis, Haemophilus influenzae, Salmonella
species and Shigella species.

Indications :

Curisafe is indicated in the treatment of infections caused by susceptible
strains of Gram-positive and Gram-negative bacteria:
* Infections of the Respiratory Tract; such as tonsillitis, pharyngitis,
laryngitis, bronchitis, bronchopneumonia, bronchiectasis, pulmonary
abscess, empyema, pleurisy, sinusitis.Slnd otitis media.
* Infections of the Skin and Soft Tissues; such as cellulitis, erysipelas,
pyodermia, lymphangitis, abscesses, decubitus ulcers, mastitis,
furunculosis, impetigo and infected traumatic and postoperative wounds.
* Infections of the Genitourinary Tract; such as pyelonephritis, cystitis,
urethritis, adnexitis, endometritis and other gynecologic infections.
* Other Infections of the Body; such as osteomyelitis, septic arthritis,
intraabdominal infections and dental infections.