Dosage & Administration:
Posology and method of administration Route of administration: Oral.
1. Local fibrinolysis: The recommended standard dosage is 15-25 mg/kg
bodyweight (i.e. 2-3 tablets) two to three times daily. For the
indications listed below the following doses may be used: 1a.
Prostatectomy: Prophylaxis and treatment of haemorrhage in high risk
patients should commence pre- or post-operatively with Kapron®
Injection; thereafter 2 tablets three to four times daily until
macroscopic haematuria is no longer present. 1b. Menorrhagia:
Recommended dosage is 2 tablets 3 times daily as long as needed for up
to 4 days. If very heavy menstrual bleeding, dosage may be increased. A
total dose of 4g daily (8 tablets) should not be exceeded. Treatment
with Kapron® should not be initiated until menstrual bleeding has
started. 1c. Epistaxis: Where recurrent bleeding is anticipated oral
therapy (2 tablets three times daily) should be administered for 7 days.
1d. Conisation of the cervix: 3 tablets three times daily. 1e.
Traumatic hyphaema: 2-3 tablets three times daily. The dose is based on
25 mg/kg three times a day. 2. Hereditary angioneurotic oedema: Some
patients are aware of the onset of the illness; suitable treatment for
these patients is intermittently 2-3 tablets two to three times daily
for some days. Other patients are treated continuously at this dosage.
3. Haemophilia: In the management of dental extractions 2-3 tablets
every eight hours. The dose is based on 25 mg/kg. Renal insufficiency:
By extrapolation from clearance data relating to the intravenous dosage
form, the following reduction in the oral dosage is recommended for
patients with mild to moderate renal insufficiency. Serum Creatinine
(Ìmol/l) Dose tranexamic acid 20-249
15 mg/kg body weight twice daily 250-500
15 mg/kg body weight/day Children's dosage: This should be
calculated according to body weight at 25 mg/kg per dose. However, data
on efficacy, posology and safety for these indications are limited.
Elderly patients: No reduction in dosage is necessary unless there is
evidence of renal failure .