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Treflucan

Treflucan

Increases effect of theophylline, anticoagulants, cyclosporin, oral hypoglycaemics, terfenadine. reduced effect: rifampicin

Description

Class: Antifungals (Anti-infectives)

Mechanism of Action: The polyene antiobiotics (amphotericin, nystatin) bind to sterols on fungal cell membranes to deform the cells. the imidazoles (clotrimazole, ketoconazole, miconazole, isoconazole, tioconazole) cause lethal accumulation of hydrogen peroxide in fungal cell


Synonym:

Molecular Formulae: C13H12FN6O = 306.3

Precautions: Hypersensitivity. liver disease. co administration with terfenadine or cisapride.

Indications/Uses: Candida infections 50-200mg daily, with or without food. crytococcal meningitis 200-400mg daily.

Interactions: Increases effect of theophylline, anticoagulants, cyclosporin, oral hypoglycaemics, terfenadine. reduced effect: rifampicin.